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Chronic inflammation, endoplasmic reticular stress, and OxS caused by glycolipid toxicity are all related to the progression of -cell failure [29, 30]

Therefore, they should stay dormant and only become active when vascular damage occurs

10.1016/S0140-6736(12)62163-1 59 HinmanA.HolstC

When administered to newly hatched chicks, SynComBac10 promoted early colonization of segmented filamentous bacteria, inducing Th17 cell-mediated mucosal immunity and conferring significant resistance to Salmonella challenge, as evidenced by reduced bacterial loads, attenuated systemic inflammation, and improved intestinal barrier integrity